Anal fissure topical treatment

To treat anal fissure, internal anal sphincterotomy may be associated with surgical risks and incidence of incontinence. Botulinum toxin injection into the anal sphincter is invasive and expensive. Headache and hypotension hindered topical treatment with glyceryl trinitrate. Greater patient compliance, potentiated efficacy, reduced side effects, and lower cost are the major advantages offered by the combination therapy. Therefore, combination topical gels of nifedipine NIF , lidocaine hydrochloride LDH and betamethasone valerate BMV were prepared and evaluated regarding viscosity, pH, drug content, and in vitro release. Compatibility study of drug—drug and drug-excipient mixtures preceded the formulation.
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Anal Fissures: Nitroglycerin Ointment

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Potential combination topical therapy of anal fissure: development, evaluation, and clinical study†

Your doctor will likely ask about your medical history and perform a physical exam, including a gentle inspection of the anal region. Often the tear is visible. Usually this exam is all that's needed to diagnose an anal fissure. An acute anal fissure looks like a fresh tear, somewhat like a paper cut.
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A quick guide to managing anal fissures

The goal of anal fissure treatment is to lower the pressure on the anal canal by making stools soft, and to ease discomfort and bleeding. Conservative treatments are tried first and include one or more of the following:. These practices heal most fissures 80 to 90 percent within several weeks to several months.
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For the best experience on htmlWebpackPlugin. Application of a 0. You rub a pea-sized dot of cream on the fissure twice a day. It is a good idea to either wear gloves when applying the nitroglycerin cream or wash your hands right after. The skin on your fingers can absorb the medicine and increase your chance of side effects.
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